Davood Khodadad Nr3.ps

Dual-wavelength digital holographic shape measurement using speckle movements and phase gradients

Wilson Aguilar Mamani Nr3.ps

i Acknowledgements iii List of Papers v

Ahmed Al-Rubaei Nr3.ps

......................................................................................................V SAMMANFATTNING ................................................................................... VII TABLE OF CONTENTS ................................................................................. IX LIST OF PAPERS............................................................................

Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors.

N-Methyl-D-aspartate receptors (NMDARs) composed of NR1 and NR3 subunits differ from other NMDAR subtypes in that they require glycine alone for activation. However, little else is known about the activation mechanism of these receptors. Using NMDAR glycine-site agonists/antagonists in conjunction with functional mutagenesis of the NR1 and NR3 ligand-binding cores, we demonstrate quite surprisi...

New insights into the not-so-new NR3 subunits of N-methyl-D-aspartate receptor: localization, structure, and function.

The NR3 subunits (NR3A and NR3B) are new players in a well established field of N-methyl-d-aspartate (NMDA) receptors, previously involving the NR1 and NR2 subunits. Their incorporation into conventional NMDA receptors forms glutamate-activated NR1/NR2/NR3 triheteromers, whereas the omission of the glutamate-binding NR2 subunits results in excitatory glycine-activated NR1/NR3 diheteromers. Thes...